How Blood Genetics Works
Human blood type is largely determined by two distinct genetic systems working at the same time: the ABO system and the Rh system. You inherit alleles (versions of genes) from both your biological mother and father.
Dominant vs Recessive Genes
In the ABO system, the A and B genes are dominant, while the O gene is recessive.
- If you inherit an A gene from mom and an O gene from dad, your blood type will be A, because A overpowers O. We call this blood type A, but your genotype is actually AO.
- Because O is recessive, the only way a person can have Type O blood is if they inherited an O gene from both parents (Genotype OO).
- If you inherit an A gene from one parent and a B from the other, they share dominance. You will have Type AB blood.
Understanding the Rh Factor (+ or -)
The Rhesus (Rh) factor indicates the presence of a specific protein on the surface of your red blood cells. If you have it, you are Rh positive (+). If you lack it, you are Rh negative (-).
Genetically, positive (+) is a dominant trait, while negative (-) is recessive. Therefore:
- Two Rh Negative parents will always have an Rh Negative child.
- Two Rh Positive parents will usually have an Rh Positive child but can have an Rh Negative child if both happen to carry a hidden negative gene.